Sarcoidosis and calcium homeostasis disturbances—Do we know where we stand?
Identifieur interne : 000441 ( Main/Exploration ); précédent : 000440; suivant : 000442Sarcoidosis and calcium homeostasis disturbances—Do we know where we stand?
Auteurs : Łukasz Gwadera [Pologne] ; Adam Jerzy Białas [Pologne] ; Mikołaj Aleksander Iwa Ski [Pologne] ; Paweł G Rski [Pologne] ; Wojciech Jerzy Piotrowski [Pologne]Source :
- Chronic Respiratory Disease [ 1479-9723 ] ; 2019.
Abstract
The majority of cases involving hypercalcemia in the setting of sarcoidosis are explained by the overproduction of calcitriol by activated macrophages. Vitamin D takes part in the regulation of granuloma formation. However, using vitamin D metabolites to assess the activity of the disease is still problematic, and its usefulness is disputable. In some cases, though, a calcium metabolism disorder could be a valuable tool (i.e. as a marker of extrathoracic sarcoidosis). Although sarcoidosis does not cause a decrease in bone mineral density, increased incidence of vertebral deformities is noted. Despite increasing knowledge about calcium homeostasis disorders in patients with sarcoidosis, there is still a need for clear guidelines regarding calcium and vitamin D supplementation in these patients.
Url:
DOI: 10.1177/1479973119878713
PubMed: 31718265
PubMed Central: 6854763
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>The majority of cases involving hypercalcemia in the setting of sarcoidosis are explained by the overproduction of calcitriol by activated macrophages. Vitamin D takes part in the regulation of granuloma formation. However, using vitamin D metabolites to assess the activity of the disease is still problematic, and its usefulness is disputable. In some cases, though, a calcium metabolism disorder could be a valuable tool (i.e. as a marker of extrathoracic sarcoidosis). Although sarcoidosis does not cause a decrease in bone mineral density, increased incidence of vertebral deformities is noted. Despite increasing knowledge about calcium homeostasis disorders in patients with sarcoidosis, there is still a need for clear guidelines regarding calcium and vitamin D supplementation in these patients.</p>
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<name sortKey="Iwa Ski, Mikolaj Aleksander" sort="Iwa Ski, Mikolaj Aleksander" uniqKey="Iwa Ski M" first="Mikołaj Aleksander" last="Iwa Ski">Mikołaj Aleksander Iwa Ski</name>
<name sortKey="Piotrowski, Wojciech Jerzy" sort="Piotrowski, Wojciech Jerzy" uniqKey="Piotrowski W" first="Wojciech Jerzy" last="Piotrowski">Wojciech Jerzy Piotrowski</name>
</country>
</tree>
</affiliations>
</record>
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